A Common Haplotype of the TNF Receptor 2 Gene Modulates Endotoxin Tolerance

A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.

Endotoxin tolerance is characterized by the suppression of further TNF release upon recurrent exposure to LPS. This phenomenon is proposed to act as a homeostatic mechanism preventing uncontrolled cytokine release such as that observed in bacterial sepsis. The regulatory mechanisms and interindividual variation of endotoxin tolerance induction in man remain poorly characterized. In this paper, ...

A labile transcriptional repressor modulates endotoxin tolerance

Tolerance to bacterial lipopolysaccharide (LPS, endotoxin) is an adaptive cellular process whereby exposure to endotoxin induces a subsequent hyporesponsive state characterized by decreased levels of LPS-induced cytokine mRNA and protein. We demonstrate, in a human promonocytic cell line, THP-1, that endotoxin tolerance is manifested by decreased LPS-induced interleukin 1 beta (IL-1 beta) trans...

Endotoxin IL - 1 Receptor - Associated Kinase Modulates

john steinbeck: friend of the american common man

in his last years of life americans had almost forgotton steinbeck, and those who had not, occasionally criticized him for supporting and praising the u. s. military intervention in the vietnam war. althought ateinbeck incorporates different themes into his works, each one bears many signs of his concern and sympathy for america and the american common people in particular. steinbecks to a god ...

Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

A genomic region on distal mouse chromosome 1 and its syntenic human counterpart 1q23-42 show strong evidence of harboring lupus susceptibility genes. We found evidence of linkage at 1q32.2 in a targeted genome scan of 1q21-43 in 126 lupus multiplex families containing 151 affected sibpairs (nonparametric linkage score 2.52, P = 0.006). A positional candidate gene at 1q32.2, complement receptor...